London Skolars 2021 Betfred League 1 fixtures:
| RD | DATE | OPPONENT | VENUE | HOME/AWAY | LOCAL TIME |
| 1 |
Saturday 8th May |
North Wales Crusaders | New River Stadium | Home | 15:30 |
| 2 | Sunday 16th May | Workington Town | Derwent park | Away | 14:00 |
| 3 | Sunday 23rd May | Coventry Bears | Butts Park Arena | Away | 15:00 |
| 4 | Saturday 29th May | West Wales Raiders | Stebonheath Park | Away | 15:00 |
| 5 | Sunday 6th June | Doncaster RLFC | Keepmoat Stadium | Away | 15:00 |
| 6 | Saturday 12th June | Hunslet RLFC | New River Stadium | Home | 15:30 |
| 7 | Saturday 19th June | Barrow Raiders | New River Stadium | Home | 15:30 |
| 8 | Sunday 27th June | Keighley Cougars | Cougar Park | Away | 15:00 |
| 9 | Sunday 4th July | Rochdale Hornets | Crown Oil Arena | Away | 15:00 |
| 10 | Friday 16th July | Doncaster RLFC | New River Stadium | Home | 19:00 |
| 11 | Saturday 24th July | West Wales Raiders | New River Stadium | Home | 15:30 |
| 12 | Saturday 31st July | Coventry Bears | New River Stadium | Home | 15:30 |
| 13 | Saturday 7th August | Rochdale Hornets | New River Stadium | Home | 15:30 |
| 14 | Sunday 15th August | Hunslet RLFC | South Leeds Stadium | Away | 15:00 |
| 15 | Saturday 21st August | Keighley Cougars | New River Stadium | Home | 15:30 |
| 16 | Saturday 28th August | Barrow Raiders | Craven Park | Away | 14:00 |
| 17 | Saturday 4th September | Workington Town | New River Stadium | Home | 15:30 |
| 18 | Sunday 12th September | North Wales Crusaders | Queensway Stadium | Away | 15:00 |
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