London Skolars 2022 Betfred League 1 fixtures:
| RD | DATE | OPPONENT | VENUE | HOME/AWAY | LOCAL TIME |
| 1 |
Saturday 26th March |
Hunslet RLFC |
New River Stadium |
Home |
15:00 |
| 2 |
Saturday 9th April |
North Wales Crusaders |
New River Stadium |
Home |
15:00 |
| 3 | Sunday 17th April | Midlands Hurricanes | Forshaw Health Lane Ground | Away | 15:00 |
| 4 | Saturday 23rd April | Rochdale Hornets | New River Stadium | Home | 15:00 |
| 5 | Sunday 1st May | Keighley Cougars | Cougar Park | Away | 15:00 |
| 6 | Sunday 8th May | Swinton Lions | Heywood Road ground M33 3WB | Away | 15:00 |
| 7 | Saturday 14th May | Doncaster | New River Stadium | Home | 15:00 |
| 8 | Friday 27th May | Oldham | New River Stadium | Home | 19:00 |
| 9 | Saturday 4th June | Cornwall | Penryn RFU | Away | 15:00 |
| 10 | Saturday 11th June | West Wales Raiders | Stebonheath Park | Away | 15:00 |
| 11 | Saturday 25th June | Swinton Lions | New River Stadium | Home | 15:00 |
| 12 | Sunday 3rd July | North Wales Crusaders | Zip World Stadium | Away | 14:30 |
| 13 | Saturday 9th July | Keighley Cougars | New River Stadium | Home | 15:00 |
| 14 | Sunday 17th July | Hunslet RLFC | South Leeds Stadium | Away | 15:00 |
| 15 | Sunday 24th July | Rochdale Hornets | Crown Oil Arena | Away | 15:00 |
| 16 | Saturday 30th July | Cornwall RLFC | New River Stadium | Home | 15:00 |
| 17 | Saturday 6th August | West Wales Raiders | New River Stadium | Home | 15:00 |
| 18 | Sunday 14th August | Oldham | Vestacare Stadium | Away | 15:00 |
| 19 | Saturday 27th August | Midlands Hurricanes | New River Stadium | Home | 15:00 |
| 20 | Sunday 4th September | Doncaster | Keepmoat Stadium | Away | 15:00 |
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